Endurance Training Regulates Expression of Some Angiogenesis-Related Genes in Cardiac Tissue of Experimentally Induced Diabetic Rats

Exercise can ameliorate cardiovascular dysfunctions in the diabetes condition, but its precise molecular mechanisms have not been entirely understood. The aim of present study was to determine impact endurance training on expression angiogenesis-related genes cardiac tissue diabetic rats. Thirty adults male Wistar rats were randomly divided into three groups (N = 10) including (DT), sedentary (SD), and healthy (SH), which induced by a single dose streptozotocin (50 mg/kg). Endurance (ET) with moderate-intensity performed motorized treadmill for six weeks. Training duration speed increased during five weeks, they kept constant at final week, slope zero all stages. Real-time polymerase chain reaction (RT-PCR) analysis used measure myocyte enhancer factor-2C (MEF2C), histone deacetylase-4 (HDAC4) Calmodulin-dependent protein kinase II (CaMKII) tissues Our results demonstrated that weeks ET gene MEF2C significantly (p < 0.05), caused significant reduction HDAC4 CaMKII DT compared SD 0.05). We concluded could play critical role ameliorating dysfunction condition regulating some tissues.